Antibody-mediated neuronal cell signaling in behavior and movement disorders

Christine A Kirvan; Susan E Swedo; Lisa A Snider; Madeleine W Cunningham

doi:10.1016/j.jneuroim.2006.06.017

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Antibody-mediated neuronal cell signaling in behavior and movement disorders

Journal article

Peer reviewed

Antibody-mediated neuronal cell signaling in behavior and movement disorders

Christine A Kirvan, Susan E Swedo, Lisa A Snider and Madeleine W Cunningham

Journal of neuroimmunology, Vol.179(1), pp.173-179

2006

DOI: https://doi.org/10.1016/j.jneuroim.2006.06.017

Handle:

https://hdl.handle.net/20.500.12741/rep:6093

PMID: 16875742

Abstract

Autoimmunity

Streptococci

Behavior

Chorea

Behavioral and movement disorders may have antibody responses where mimicry and signal transduction may lead to neuropsychiatric abnormalities. In our study, antibodies in pediatric autoimmune neuropsychiatric disorders associated with streptococci (PANDAS) reacted with the neuronal cell surface and caudate–putamen and induced calcium–calmodulin dependent protein (CaM) kinase II activity in neuronal cells. Depletion of serum IgG abrogated CaM kinase II cell signaling and reactivity of CSF was blocked by streptococcal antigen N-acetyl-beta- d-glucosamine (GlcNAc). Antibodies against GlcNAc in PANDAS sera were inhibited by lysoganglioside G M1. Results suggest that antibodies from an infection may signal neuronal cells in some behavioral and movement disorders.

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Title: Antibody-mediated neuronal cell signaling in behavior and movement disorders
Creators: Christine A Kirvan - Department of Biological Sciences, California State University, Sacramento, 6000 J Street, Sacramento, CA 95618-6077, USA
Susan E Swedo - Pediatrics and Developmental Neuropsychiatry Branch, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, 35 Convent Dr., BG 35 MSC 3710, Bethesda, MD 20814, USA
Lisa A Snider - Pediatrics and Developmental Neuropsychiatry Branch, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, 35 Convent Dr., BG 35 MSC 3710, Bethesda, MD 20814, USA
Madeleine W Cunningham - Department of Microbiology and Immunology, University of Oklahoma, HSC, 975 N. E. 10th Street, Biomedical Research Center Room 217, Oklahoma City, OK 73104, USA
Academic Unit: Department of Biological Sciences
Publisher: Elsevier B.V
Publication Details: 2006
Identifiers: 99257847125701671; https://hdl.handle.net/20.500.12741/rep:6093; https://doi.org/10.1016/j.jneuroim.2006.06.017
Language: English

Antibody-mediated neuronal cell signaling in behavior and movement disorders

Abstract

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