Abstract
Triazoles are a type of heterocyclic amine which can be found in a variety of useful and bioactive compounds, ranging from agrochemicals and photochemical products to antifungal drugs and pharmaceutical substances. The classic synthesis for the 5-membered triazole ring is accomplished through a synthetic approach known as “Click Chemistry”. The syntheses of a variety of 4,5-disubstituted-1,2,3-triazoles and bis-1,2,3-triazoles (Figure 1) have been carried out via a new, “Green” synthetic method which involves the absence of solvent and catalyst, and is carried out using a domestic microwave oven. This new synthetic method provides a fast and efficient technique to obtain various types of triazoles in good to excellent yields. It has also been shown to be an effective alternative to the classical synthesis, without the use of toxic and environmentally unsafe solvents or catalysts.