Abstract
A new, greener method for the synthesis of the anesthetic compound lidocaine has been developed for use in the student laboratory. Current synthetic procedures for the three-step process were evaluated using a series of guidelines based on the 12 principles of green chemistry. Adaptations were then made to the procedure that resulted in a more environmentally friendly, sustainable chemical process. From an economic standpoint, the cost of reagents is reduced by 25% in this new method, while obtaining yields comparable to those reported in literature for each step. The new method retains the features that are fundamental to student laboratory experiments - hands-on experience performing important organic reactions and incorporation of several important laboratory techniques. In addition, the concepts of green chemistry are presented in a practical, application-based manner, while the production of a well-known product adds interest to the laboratory experience.